| RK | PLAYER NAME | TEAM | BYE WEEK | AGE |
|---|---|---|---|---|
| 1 | Jonathan Taylor | IND | 14 | 23 |
| 2 | Saquon Barkley | NYG | 9 | 25 |
| 3 | Kenneth Walker III | SEA | 11 | 22 |
| 4 | Christian McCaffrey | SF | 9 | 26 |
| 5 | Breece Hall | NYJ | 10 | 21 |
| 6 | Travis Etienne Jr. | JAC | 11 | 23 |
| 7 | Austin Ekeler | LAC | 8 | 27 |
| 8 | Nick Chubb | CLE | 9 | 26 |
| 9 | D'Andre Swift | DET | 6 | 23 |
| 10 | Joe Mixon | CIN | 10 | 26 |
| 11 | Javonte Williams | DEN | 9 | 22 |
| 12 | Dalvin Cook | MIN | 7 | 27 |
| 13 | Rhamondre Stevenson | NE | 10 | 24 |
| 14 | Josh Jacobs | LV | 6 | 24 |
| 15 | Derrick Henry | TEN | 6 | 28 |
| 16 | Alvin Kamara | NO | 14 | 27 |
| 17 | Najee Harris | PIT | 9 | 24 |
| 18 | Dameon Pierce | HOU | 6 | 22 |
| 19 | Tony Pollard | DAL | 9 | 25 |
| 20 | Aaron Jones | GB | 14 | 28 |
| 21 | Miles Sanders | PHI | 7 | 25 |
| 22 | David Montgomery | CHI | 14 | 25 |
| 23 | AJ Dillon | GB | 14 | 24 |
| 24 | J.K. Dobbins | BAL | 10 | 23 |
| 25 | Rachaad White | TB | 11 | 23 |
| 26 | Antonio Gibson | WAS | 14 | 24 |
| 27 | Brian Robinson Jr. | WAS | 14 | 23 |
| 28 | Leonard Fournette | TB | 11 | 27 |
| 29 | Khalil Herbert | CHI | 14 | 24 |
| 30 | Ezekiel Elliott | DAL | 9 | 27 |
| 31 | James Conner | ARI | 13 | 27 |
| 32 | Kareem Hunt | CLE | 9 | 27 |
| 33 | James Cook | BUF | 7 | 23 |
| 34 | Elijah Mitchell | SF | 9 | 24 |
| 35 | Clyde Edwards-Helaire | KC | 8 | 23 |
| 36 | Devin Singletary | BUF | 7 | 25 |
| 37 | Damien Harris | NE | 10 | 25 |
| 38 | Michael Carter | NYJ | 10 | 23 |
| 39 | Cam Akers | LAR | 7 | 23 |
| 40 | Isiah Pacheco | KC | 8 | 22 |
| 41 | James Robinson | NYJ | 10 | 24 |
| 42 | Alexander Mattison | MIN | 7 | 24 |
| 43 | Jeff Wilson Jr. | MIA | 11 | 27 |
| 44 | Cordarrelle Patterson | ATL | 14 | 31 |
| 45 | Tyler Allgeier | ATL | 14 | 22 |
| 46 | Jamaal Williams | DET | 6 | 27 |
| 47 | D'Onta Foreman | CAR | 13 | 26 |
| 48 | Zamir White | LV | 6 | 23 |
| 49 | Darrell Henderson Jr. | JAC | 11 | 25 |
| 50 | Kenneth Gainwell | PHI | 7 | 23 |
| 51 | Isaiah Spiller | LAC | 8 | 21 |
| 52 | Rashaad Penny | SEA | 11 | 26 |
| 53 | Gus Edwards | BAL | 10 | 27 |
| 54 | Chase Edmonds | DEN | 9 | 26 |
| 55 | Nyheim Hines | BUF | 7 | 26 |
| 56 | Melvin Gordon III | KC | 8 | 29 |
| 57 | Kyren Williams | LAR | 7 | 22 |
| 58 | Raheem Mostert | MIA | 11 | 30 |
| 59 | Tyrion Davis-Price | SF | 9 | 22 |
| 60 | J.D. McKissic | WAS | 14 | 29 |
| 61 | Chuba Hubbard | CAR | 13 | 23 |
| 62 | D'Ernest Johnson | CLE | 9 | 26 |
| 63 | Eno Benjamin | HOU | 6 | 23 |
| 64 | Pierre Strong Jr. | NE | 10 | 23 |
| 65 | Kenyan Drake | BAL | 10 | 28 |
| 66 | Hassan Haskins | TEN | 6 | 23 |
| 67 | Chris Evans | CIN | 10 | 25 |
| 68 | Keaontay Ingram | ARI | 13 | 23 |
| 69 | Sony Michel | LAC | 8 | 27 |
| 70 | Ronald Jones II | KC | 8 | 25 |
| 71 | Darrel Williams | ARI | 13 | 27 |
| 72 | Jaylen Warren | PIT | 9 | 24 |
| 73 | Samaje Perine | CIN | 10 | 27 |
| 74 | Jerome Ford | CLE | 9 | 23 |
| 75 | Jerick McKinnon | KC | 8 | 30 |
| 76 | Zack Moss | IND | 14 | 24 |
| 77 | Joshua Kelley | LAC | 8 | 25 |
| 78 | Myles Gaskin | MIA | 11 | 25 |
| 79 | Ke'Shawn Vaughn | TB | 11 | 25 |
| 80 | Dontrell Hilliard | TEN | 6 | 27 |
| 81 | Trey Sermon | PHI | 7 | 23 |
| 82 | Boston Scott | PHI | 7 | 27 |
| 83 | Mark Ingram II | NO | 14 | 32 |
| 84 | Rex Burkhead | HOU | 6 | 32 |
| 85 | Tyler Badie | BAL | 10 | 22 |
| 86 | Damien Williams | ATL | 14 | 30 |
| 87 | Kevin Harris | NE | 10 | 22 |
| 88 | Marlon Mack | DEN | 9 | 26 |
| 89 | Kene Nwangwu | MIN | 7 | 24 |
| 90 | Justin Jackson | DET | 6 | 26 |
| 91 | DeeJay Dallas | SEA | 11 | 24 |
| 92 | Trestan Ebner | CHI | 14 | 23 |
| 93 | Ty Johnson | NYJ | 10 | 25 |
| 94 | Jaret Patterson | WAS | 14 | 22 |
| 95 | Mike Boone | DEN | 9 | 27 |
| 96 | Matt Breida | NYG | 9 | 27 |
| 97 | JaMycal Hasty | JAC | 11 | 26 |
| 98 | Mike Davis | BAL | 10 | 29 |
| 99 | Ty Chandler | MIN | 7 | 24 |
| 100 | Snoop Conner | JAC | 11 | 22 |
| 101 | Latavius Murray | DEN | 9 | 32 |
| 102 | Jermar Jefferson | DET | 6 | 22 |
| 103 | Craig Reynolds | DET | 6 | 26 |
| 104 | Darrynton Evans | CHI | 14 | 24 |
| 105 | Justice Hill | BAL | 10 | 25 |
| 106 | Benny Snell Jr. | PIT | 9 | 24 |
| 107 | Demetric Felton Jr. | CLE | 9 | 24 |
| 108 | Tevin Coleman | SF | 9 | 29 |
| 109 | Giovani Bernard | TB | 11 | 31 |
| 110 | Ameer Abdullah | LV | 6 | 29 |
| 111 | Salvon Ahmed | MIA | 11 | 23 |
| 112 | Duke Johnson Jr. | BUF | 7 | 29 |
| 113 | Travis Homer | SEA | 11 | 24 |
| 114 | Dare Ogunbowale | HOU | 6 | 28 |
| 115 | Tyler Goodson | GB | 14 | 22 |
| 116 | Brandon Bolden | LV | 6 | 32 |
| 117 | Zonovan Knight | NYJ | 10 | 21 |
| 118 | Tony Jones Jr. | SEA | 11 | 25 |
| 119 | Larry Rountree III | LAC | 8 | 23 |
| 120 | Sincere McCormick | LV | 6 | 22 |
| 121 | Jerrion Ealy | KC | 8 | 22 |
| 122 | D'Vonte Price | IND | 14 | 23 |
| 123 | Ty Montgomery | NE | 10 | 29 |
| 124 | Qadree Ollison | DAL | 9 | 26 |
| 125 | Anthony McFarland Jr. | PIT | 9 | 24 |